Purpose The Nuss procedure, also known as Minimally Invasive Repair of Pectus Excavatum (MIRPE), is recognised to cause high levels of postoperative pain. Intercostal nerve cryoablation during MIRPE is a technique that results in extended analgesia for 3-6 months after surgery. We describe our early experience with cryoablation in MIRPE in two hospitals in Brisbane. Methodology Retrospective chart reviews were conducted of patients who have undergone cryoablation for MIRPE since its introduction in Brisbane and patients who underwent MIRPE without cryoablation immediately before its introduction. Oral morphine equivalents were calculated for opiate medications administered in hospital. The two cohorts were compared using unpaired t-tests. Results 17 patients (average age 15.8 yrs) underwent MIRPE with cryoablation and were compared to 17 who underwent MIRPE without cryoablation therapy (average age 15.7 yrs). Cryoablation significantly reduced the length of stay-average 3 days compared to 5.4 days in patients without cryoablation (p<0.05). Cryoablation also significantly reduced inpatient opiate use- average oral morphine equivalent 110mg in patients who received cryoablation compared to 489mg in those who did not (p<0.05). None of the patients who underwent cryoablation were discharged on long-acting opiates compared to 81 % of patients with no ablation. Conclusion Intercostal cryoablation for MIRPE significantly reduces postoperative pain and duration of hospitalisation. Our presentation will describe our results and the technique of cryoablation, including the use of adjunctive local anaesthetic intercostal nerve blocks.