Background: Despite the global advancements in gender equity, female surgeons remain under-represented within leadership, research, and entrepreneurship roles, reflecting the broader gender inequity within the scientific and corporate world. Female surgeons are leaders and creative problem solvers who continually adapt techniques, instruments, and clinical scenarios to optimize the outcomes for their patients. However , there remains a wide valley between the surgeon on the shop floor who understands the clinical treatment challenges and conceives an innovative idea, the engineers who can create the prototype of an instrument to address the challenge and the investors who can fund its development pathway towards a product that can benefit patients. Aim: We have two aims. First, to inform the surgical community of the existing roadblocks facing the female surgeon innovator. Second, to inspire aspiring and existing female surgeons to pursue opportunities in the medical technology and entrepreneurship world. Methods: We outline the challenges cited in the literature that prevent female surgeons from pursuing pathways within entrepreneurship and innovation . We then discuss strategies to overcome these challenges. Finally, we summarize a series of resources and pathways, such as Commonwealth Industry fellowships, that are available to female surgeons at various career stages, who want to work with or within the MedTech and entrepreneurship ecosystem. Conclusion: Female surgeons have the potential to become great innovators and entrepreneurs, as exemplified by some well-known names both in Australia and overseas.