Purpose Biodegradable Temporising Matrix (BTM) is a synthetic dermal substitute which has been used primarily in burns and reconstructive surgery. Use of BTM for diabetic foot ulceration has only recently been described in the literature, and is previously limited to small cohort studies. BTM facilitates wound coverage to prevent infection, limits pain with dressings, and prepares wounds or prevents the requirement for skin grafts or flaps. This project reports the experience of BTM use in Vascular Surgical patients for both diabetic and non-diabetic lower limb ulceration at the Sunshine Coast University Hospital. Methodology All patients who underwent application of BTM at the Sunshine Coast University Hospital were included. Patients were prospectively collated and outcomes retrospectively reviewed to assess success of grafting and wound healing. BTM was applied following revascularisation in patients who required arterial intervention. Following BTM application, patients routinely underwent negative pressure wound therapy dressings as an inpatient, followed by close outpatient wound monitoring. Further applications of BTM and split thickness skin grafting were performed as required. Results Nine patients underwent application of BTM for lower limb wounds. Five (56%) were diabetic foot ulcers and four (44%) from other causes. Two (22%) patients required subsequent layering of further pieces of BTM to fill the wound defect. Three (33%) patients progressed to have subsequent split thickness skin grafting performed. No grafts failed or required removal. Conclusion Based on our experience, application of BTM is safe and effective for the management of both diabetic and non-diabetic ulceration in the Vascular Surgery population.