Background: In ancient Greece, physicians like Hippocrates made significant strides in wound healing but their contributions to Plastic Surgery were relatively modest. Aulus Cornelius Celsus, living between 25 BC and 50 AD, authored "De Medicina," a seminal work that was rediscovered in 1443. Without a direct medical background, Celsus harmoniously blended Hippocratic principles with the surgical advancements of Alexandria to advance Plastic Surgery. Methods: Within "De Medicina," particularly in books VII and VIII, Celsus introduced groundbreaking techniques in oculoplastics and lip repair. He provided the earliest documented procedures for blepharoplasty, detailing the treatment of trichiasis and entropion. His innovations included the use of double quadrilateral advancement flaps for repairing lips, rotation flaps for triangular defects, and the first known applications of surgical relaxing incisions. Furthermore, he addressed post-circumcision issues, syndactyl separation, and methods for reconstructing the glans. Results: The enduring legacy of Celsus in Plastic Surgery is marked by his precise descriptions and innovative techniques, which not only influenced his contemporaries, including Galen, but also set a foundational standard for future surgical practices. Conclusions: Despite not being a practicing physician, Aulus Cornelius Celsus left an indelible mark on Plastic Surgery through "De Medicina." His detailed accounts and methodical approach significantly propelled the field forward. Ref: Köckerling F, Köckerling D, Lomas C (2013) “Cornelius Celsus– ancient encyclopedist, surgeon-scientist, or master of surgery?,” Langenbeck’s Arch Surg 398(4):609–616.