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RACS ASC 2024

Tolerability of transperineal prostate biopsy under local anaesthetic using pre-emptive over-the-counter analgesia: an interventional study in patients with abnormal clinical prostate findings at the Sydney Adventist Hospital

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Institution: Sydney Adventist Hospital - NSW, Australia

Objective: Transperineal prostate (TP) biopsy is the key diagnostic tool for evaluating prostate cancer and may be feasible under local anaesthetic (LA) alone. However, concerns about its tolerability encourage use of a multimodal analgesia approach. Pre-emptive over-the-counter analgesia with LA may provide a simple and low-risk option. The objective of this study was to investigate the effects of over-the-counter analgesia on TP biopsies conducted under LA. Methods: This interventional single-centre study investigated 160 participants who undertook a TP biopsy under LA, with and without pre-emptive analgesia (paracetamol 1g and ibuprofen 400mg). Pain tolerability was measured using a visual analogue scale (VAS) at three procedural points (probe insertion, LA infiltration, biopsy); an overall average VAS score was subsequently calculated. Abstracted secondary variables include patient details (age, prostate size, PSA level) and biopsy details (number of cores, volume of LA used) and preferability for LA use in future TP biopsies. Inferential statistical analysis was performed using Wilcoxon’s Rank Sum non-parametric test, Pearson’s test of correlation, and Pearson’s Chi-squared test. Results: The groups were comparable in age, prostate size, and PSA level. Median VAS scores were consistently lower in the intervention cohort, but without statistical significance. Higher volume of LA was associated with lower overall VAS (p=0.03). LA was strongly preferred over GA for hypothetical future TP biopsies in both cohorts. Conclusions: Pre-emptive analgesia does not significantly improve tolerability of TP biopsy under LA. Our study substantiates evidence that TP biopsy is generally well-tolerated under LA and preferred over GA.

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Dr Shelley Wang - , Dr Yuxi Xu - , Dr Meredith Cheng - , Dr Anika Jain - , Prof Henry Woo -