Introduction Negative Pressure Wound Therapy (NPWT) has been introduced as an acute burn care adjunct, with research suggesting that application at initial debridement may decrease time to re-epithelialisation by 22%. The implication of burn stratification via depth and the overall clinical significance is unknown. Therefore, the aim of this study was to assess the effect reducing time to re-epithelialisation by 22% has on therapeutic morbidity when stratified via depth. Methods This Australian, singe site, retrospective cohort study from a quaternary paediatric burns unit used burns registry data from 2014 – 2015; the final year before NPWT was introduced into acute burn care. The primary outcome was the effect reducing time to re-epithelialisation by 22% had on scar clinic referral, stratified via depth. Results 803 participants were included. Mean time to re-epithelialisation was 21.3 days (95% CI 18.92 – 23.71) for deep dermal partial thickness burns (DPT). 212 patients (26.4%) were referred to scar clinic, 63.2% were DPT. The odds ratio of being referred to scar clinic increased by 7.6 (4.4 – 13.1; p <0.001) for each increase in burn depth. At day 21, there was a 67.19% (58.82 – 75.57) probability of being referred to scar outpatient clinic (SOC). When reducing the time to re-epithelialisation by 22%, this same burn would heal on day 16 and have a 44.92% (35.59 – 54.25%) probability of being referred to SOC – a reduction of 22.27%. Conclusion From these data, the addition of NPWT as an acute burn care adjunct is likely clinically significant in deep partial thickness burns as it significantly decreases the probability of scar clinic referral.