Purpose: Sarcopenia is defined as the global and gradual decline in skeletal muscle mass, strength, and function, and is therefore an objective marker of frailty. Early identification of high-risk patients is invaluable to clinicians offering oncological resections. The aim of this study was to evaluate the impact of sarcopenia on perioperative outcomes in patients with colorectal cancer (CRC). Methodology: Sarcopenia was estimated by measuring the cross-sectional area of the psoas muscles (total psoas area or TPA), at the third lumbar vertebra (L3) on pre-operative computed-tomography scans. The total psoas index (TPI) was calculated by normalising TPA for patient height. Sarcopenia was defined using published gender-specific cut-off points. Results: 356 patients with CRC were identified as having undergone emergency or elective surgery between 2018 to 2023 at a single tertiary centre of Far North Queensland. Of these, 150 were female, mean age was 66.1 years (95% CI: 64.6-67.5) and mean BMI was 27.5 (95% CI: 26.8-28.2). Both sarcopenic patients (SP) (52/139 = 37.4%) and non-sarcopenic patients (NSP) (55/217 = 25.34%) were significantly associated with surgical complications (p=0.041). SP mean length of stay (LOS) in hospital of 11.9 days was found to be significantly greater compared to NSP LOS of 8.35 days (p=0.001). SP were significantly associated with surgical site infection (SSI) with an SSI rate of 11.51% compared to 5.5% in NSP (p=0.041). Conclusion: Sarcopenia is an important prognostic indicator associated with several perioperative complications in patients with CRC.