Introduction: Negative Pressure Wound Therapy (NPWT) in acute burn care may decrease the time to re-epithelialisation by more than 20%. Despite this, the perceived burden of use have so far limited the use of NPWT. This might be minimised by utilising the small, ultra-portable, single-use NPWT device PICO™ as opposed to larger devices. This research primarily assessed the feasibility, acceptability and safety of PICO™ in paediatric burns. Secondary outcomes include time to re-epithelialisation, pain, itch, cost and scar formation. Methods and analysis: This single site, prospective, pilot randomised control trial was conducted in an Australian quaternary paediatric burns centre. Participants were aged ≤16-years, otherwise well and managed within 24-hours of sustaining a burn that fits beneath a PICO™ dressing. Thirty participants were randomised to one of three groups: Mepitel® and ACTICOAT™, Mepitel®, ACTICOAT™ and PICO™; and Mepitel®, ACTICOAT™ Flex and PICO™. Patient outcomes were recorded at each dressing change to assess efficacy and safety outcomes until three months post burn wound re-epithelialisation. Surveys, randomisation and data storage were undertaken via online platforms and physical data storage collated at the Centre for Children’s Health Research, Brisbane, Australia. Analysis was done using Stata statistical software. Results: Data has finished being collated and will be presented at the RACS scientific forum. Ethics and Registration: Ethics has been obtained from Queensland Health and Griffith Human Research Ethics committees including a site-specific approval. Registration is with the Australian and New Zealand Clinical Trials Registry (ACTRN12622000009718). A grant was provided by Smith & Nephew which partially funded the trial.