Purpose: The literature suggests that tantalum (Ta) implants may possess antibacterial properties. However, there is no consensus on Ta's preventive effects on the periprosthetic joint infection (PJI) in revision total knee arthroplasty (rTKA). Question: What is the incidence rate of PJI following rTKA with Ta implants, both septic and all-cause revision reasons? Is there a difference in the rate of PJI after rTKA performed with Ta implants versus non-Ta implants? Methodology: Using five main databases, we searched for articles reporting the rate of PJIs following rTKA with Ta implants until Jan 2022. The PJI rates for the Ta group were pooled, compared to the control group, and presented as odds ratios (OR) and 95% confidence intervals (CI) in forest plots. Results: Thirty eligible studies with 881 knees were identified. The overall PJI rates for rTKA with Ta implants were 8.1% (CI= 6.6%-9.9%); specifically, when rTKA was performed for septic revision, the infection rate was 15.7% (95% CI= 11.7%-20.7%) for rTKAs. Based on the comparative analysis, the rate of PJI between the Ta and none-Ta groups (three studies) was similar (OR=0.52, 95% CI = 0.13–2.0, P=0.35). Conclusion: PJI is a serious complication following both all-cause and septic-cause rTKA, and it is not uncommon even for patients using Ta implants. The rate of PJI after rTKA was similar for Ta implants and non-Ta implants. Further investigation with a high level of evidence is mandatory to draw a definitive conclusion regarding the potential role of Ta derivatives on infection rates following rTJA, especially in septic revision.