Purpose: Posterolateral congenital diaphragmatic hernia (CDH) occurs in approximately 1 in 3000 births. The defect size determines surgical repair with large defects require patch closure. Patch materials include polytetrafluoroethylene (PTFE, Gore-Tex) and Surgisis, however, there are associated complications with each material used. There is potential to explore new solutions with technology like biofabrication. Methodology: A literature review was performed for patch repair for CDH with a focus on potential new patch materials; synthetic, biologic, or composite. The keywords used in the search included “Congenital diaphragmatic hernia/CDH”, “treatment for CDH”, “biomaterials”, “bioengineering”, and “tissue engineering.” Results: Studies by Jancelewicz et al., 2013 and Ruhrnschopf et al., 2021 compared synthetic, biological, and composite patch materials, the results from the small sample showed that Gore-Tex has a recurrence rate ranging from 4-21%, while surgisis has a higher recurrence rate at 50%. A potential candidate patch material is ovine forestomach matrix (OFM) which has been used in other hernias (Overbeck et al., 2020), another potential patch is thermoplastic polyurethane (TPU) and silicone composite which was made to have similar properties to Gore-Tex (Mohsenzadeh et al., 2023), however, these need further testing in animal studies before patient trials. Conclusion: There is a need for continued development and assessment of CDH patch material and biofabrication remains a promising solution. Current potential patches include OFM and TPU/silicone but require further prospective studies to find the ‘ideal’ patch for CDH repairs. There is a role for multi-centre study into patches used and outcomes in CDH repair.