Aims: Medullary carcinoma of the colon (MCC)is a rare subtype of adenocarcinoma, first described in 1999. Clinically known to have a favourably prognosis in comparison to poorly differentiated cancers, it is invariably associated with mismatch gene repair, and morphologically characterised by sheets of malignant cells with indistinct boundaries amongst other features. This is an observational study of Hobart’s patient population with medullary cancer, and compares data with the current literature.METHODS: We performed a search of the pathological database at our institution for medullary adenocarcinomas between the years of 2016-2023 and reviewed their clinical information to collect all relevant data including patient history, hospital admissions. surgery and clinic visits. We then performed a literature search using Pubmed for search terms medullary cancer/carcinoma of the colon/colorectum.RESULTS:11 patients were found in our database, 34 papers in the literature (19 retrospective cohort studies and 13 case reports. 81.8% (vs. 73.22% in cohort studies) were female. 8/11 patients had lympho-vascular invasion (LVI) with 2/11 perineural (PNI) involvement (table1). Immunohistochemistry (IHC) demonstrated 11/11 patients’ tumours demonstrating MLH1 and PMS2 loss, with presence of MSH2 and MSH6. Cohort studies demonstrated 302/1897 (15.92%) patients had perineural invasion (PNI) with 1133/2151 (52.67%) demonstrating LVI. MLH1 testing was available for 192 patients, with 93.75% having loss of MLH1. CONCLUSION: MCCs tend to affect females more than males, and generally occur in the right side of the colon. Our database had a similar number of patients to national cancer databases in the literature, and had better survival outcomes.