Introduction: Breast cancer when treated with breast conserving surgery routinely requires adjuvant external beam radiation therapy (EBRT) to reduce local recurrence and generally continues for 4-6 weeks. This can be an obstacle for cancer patients who may not be able to meet the demands of daily irradiation. Intraoperative radiotherapy (IORT) provides a potential solution to reduce the impact on patients providing a rapid form of tumour bed irradiation during the primary surgery. Methods: This pilot study recruited 20 patients who meet inclusion criteria and 20 patients who underwent EBRT prior to availability of IORT. Inclusion criteria included >50 years, unifocal tumours <2cm and grade 1-2 invasive ductal carcinoma. Breast-Q-BCT and EORTC-QLQ-C30 questionnaires were implemented preoperatively, 2weeks postoperatively and 1year post-operatively to assess patient outcome measures. 6–8-week postoperative calls were performed to assess patient satisfaction for IORT. Cost analysis was performed comparing 20 EBRT and IORT patients. Results: Average age was 63 years. 30% of patients were current/ex-smokers and 70% of patients were non-smokers. Average tumour maximal diameter on imaging was 10.18mm. Grade 1 invasive carcinoma was found in 7 patients while 11 patients had grade 2 on biopsy. Operative specimens of nine patients had close/involved margins. 6 patients required further excision with no invasive disease on specimens. 3 patients required conversion to EBRT. Financial cost analysis and 1-year questionnaires will be presented. Follow up calls revealed 100% patient satisfaction. Conclusion: IORT is a feasible alternative to EBRT in certain patients providing limited complications and high patient satisfaction.