The concept of Regenerative Peripheral Nerve Interface (RPNI) and the integration of artificial devices with the nervous system has been an area of active research for several decades. The process typically involves implanting a scaffold or conduit at the site of nerve injury or amputation. Early Neural Interfaces (1960s-1980s): The groundwork for neural interfaces was laid with early experiments involving direct electrical stimulation of nerves and the development of rudimentary prosthetic devices. Neuroprosthetics (1980s-2000s): The focus shifted towards developing prosthetic limbs controlled by signals from the nervous system. Electrodes were implanted to pick up signals from nerves and muscles, allowing users to control prosthetics more naturally. Advancements in Regenerative Medicine (2000s-Present): With the progress in regenerative medicine, scientists explored ways to enhance the integration of artificial devices with the nervous system. This led to the development of regenerative nerve interfaces. Introduction of RPNIs (2010s-Present): Researchers began to explore the use of regenerative approaches, including the use of scaffolds and conduits, to encourage nerve regeneration and improve the connection between nerves and artificial devices. While the field of Regenerative Peripheral Nerve Interfaces is still evolving, early research and experiments have shown promising results. As technology advances and our understanding of neuroregeneration deepens, RPNIs may become an integral component of next-generation prosthetics and neuroprosthetic devices, improving the quality of life for individuals with limb impairments and neurological disorders.