Artificial dermal templates have great use in burns as they provide a scaffold for tissue. Since the invention of Integra Dermal Regeneration Template in 1980, the dermal matrix strategy for major burn care has thrived however the development, regulation and manufacture of these biological skin substitutes is resource intensive and expensive. Since then, there have been advances with synthetic skin substitutes which are constructed out of non-biological molecules and polymers. Biodegradable polyurethane has been used in bone and cartilage grafts since 2003 and used in dressings (Mepilex, Allevyn) as well as to culture keratinocytes (Tegaderm). Li et al. (2009) first proposed a biodegradable polyurethane scaffold that would maintain favourable biological properties to allow wound healing but breakdown within 18 months. This product has since been produced as Novosorb® BTM (PolyNovo, Australia) and used in clinical practice since 2012. In addition to clinical advantages, Novosorb BTM is cheaper, less complex to manufacture and obviates the need for allogenic or xenogenic materials compared to collagen based dermal templates. To date this remains the only totally synthetic dermal regeneration template available. References: Li, A., Dearman, B.L., Crompton, K.E., Moore, T.G. and Greenwood, J.E., 2009. Evaluation of a novel biodegradable polymer for the generation of a dermal matrix. Journal of burn care & research, 30(4), pp.717-728. Dearman, B.L., Li, A. and Greenwood, J.E., 2014. Optimization of a polyurethane dermal matrix and experience with a polymer-based cultured composite skin. Journal of burn care & research, 35(5), pp.437-448.