Purpose: Haemorrhoidectomy is the gold standard for definitive treatment of high-grade symptomatic haemorrhoids but is often associated with substantial pain. This systematic review aims to explore the potential of flavonoids in alleviating the postoperative symptom burden, primarily pain, following excisional haemorrhoidectomy. Methodology: A systematic review of randomised control trials on the effect of flavonoids after excisional haemorrhoidectomy, published across the databases of PubMed, MEDLINE via Ovid, and Embase via Ovid from their inception up until December 2023. Data extraction was separated into primary and secondary outcomes to assess postoperative symptom burden. A meta-analysis was performed to synthesize data extracted on postoperative pain. Results: Ten articles were identified as part of this systematic review. The meta-analysis identified statistically significant decreases in pain at 7 of the 9 postoperative checkpoints in patients given flavonoids, with the most significant degree of pain relief achieved at postoperative days 7 (p=0.0002) and 14 (p<0.0001). Four, four and three articles respectively identified reductions in postoperative bleeding, pruritus, and tenesmus. Two studies reported an associated reduced length of stay, as well as reduced analgesic consumption with flavonoid use. Conclusion: Flavonoids show promise as a means of reducing pain, bleeding, pruritus, and tenesmus associated with excisional haemorrhoidectomy. Topical formulations of flavonoids are of particular interest given the context of the wounds treated and issues with bioavailability with oral dosing.