Purpose: Desmoid tumours are connective tissue neoplasms that most commonly develop within the anterior abdominal wall. Exhibiting an infiltrative and locally aggressive growth pattern, these tumours typically do not metastasize but have a high rate of recurrence and complications. Among the rare extra-abdominal manifestations are Breast Desmoid Tumours (BDT). Recent research has proposed the presence of breast implants as a potential risk factor. Methodology: First, we present a literature review on BDT cases linked to breast implants. Second, we present a 23-year-old female with a prior cosmetic augmentation who presented to our facility with the largest BDT in the literature, weighing 2.2kg. Results: Findings from Tzur et al.'s 2017 study revealed a lower incidence of BDT following breast implants compared to the general population, with only 9.8% of 366 cases associated with silicone implants (1). Costa et al.'s 2021 study of 80 patients with BDT and prior breast implants revealed multimodal treatment approaches including surgical resection in 82% of cases, chemotherapy in 12%, sorafenib in 4%, hormonal therapy in 14% and active surveillance in 4% (1). The recurrence rate post-resection was reported at 24% within 3 years (1). Conclusion: This literature review highlights a reduced incidence of BDT following breast implants compared to the general population. However, definitively confirming a direct association between implants and BDT remains challenging. We advocate for the use of a global registry to record each case of BDT associated with implants to advance our understanding of this potential connection. References: (1) Tzur et al. Desmoid Tumor and Silicone Breast Implant Surgery: Is There Really a Connection? Aesth Plast Surg. 2018;42(1):59–63.