Introduction Epithelioid sarcoma is known as one of the rarest types of sarcomas, and it is extremely rare in the brachial plexus. Case presentation This report will detail the case of a 49-year-old lady who was diagnosed with epithelioid sarcoma over her right brachial plexus, treated with neo-adjuvant radiotherapy followed by resection and consideration of adjuvant systemic therapy. Discussion Epithelioid sarcoma of the brachial plexus is extremely rare, complete excision of the tumour is challenging due to its proximity to the neurovascular structures. Multidisciplinary discussion followed by proper planning of surgery and multi modal treatment are required in managing this complex case.