Skip to main content
RACS ASC 2024

Early experience with hypothermic oxygenated machine perfusion in kidney transplantation

Poster

Presentation Description

Institution: Austin Health - Melbourne,VIC, Australia

Purpose: This study aims to report our early experience using hypothermic oxygenated machine perfusion (HOMP) in kidney transplantation. Materials and Methods: HOMP was used to support deceased donor kidneys (5 after circulatory death and 9 after brain stem death) on an ad hoc basis between August 2023 and January 2024. Four kidneys had acute kidney injury. The median KDPI was 61(IQR 54). The median resistive indices pre and post-HOMP were 0.42(IQR 0.12) and 0.2 (IQR 0.08) respectively. The median duration of perfusion was 8.9 hours (IQR 7.6), and cold ischemic time was 16.2 hours (IQR 10.51)). The outcomes analysed were: incidence of primary non-function (PNF), delayed graft function (DGF), patient and graft survival, acute rejection, and surgical complications. Results: The median age of 14 recipients was 64 years (IQR 9). There were no PNF, and 5 cases experienced DGF. Two patients had acute rejection. All patients are off dialysis. The median eGFR at the last follow-up was 44(IQR 36)ml/min/1.73m2. Three kidneys were placed on HOMP overnight due to patient complexity and logistic reasons. Two contralateral kidneys were not utilised, and two other kidneys were initially declined by all transplant centres in the state. No machine-related issues were encountered, and no major peri-operative surgical complications. Conclusions: HOMP was able to be implemented in existing workflows and appeared to be safe and effective in this case series. It permitted use of 4 kidneys that would otherwise have been at risk of non-utilisation. It further helps improve theatre efficiency. Keywords: Hypothermic oxygenated machine perfusion, delayed graft function (DGF)

Speakers

Authors

Authors

Dr Jayanth Daniel Ezhilarasu - , Mr Ruelan Furtado - , Mr Mark Steven - , A/Prof Darren Lee - , A/Prof John Whitlam - , A/Prof Bulang He -