Non-melanocytic skin cancers are one of the common side effects of Transplant Surgery. Lifelong immunosuppression with drugs such as cyclosporine can increase the susceptibility of developing squamous cell carcinoma in solid organ transplant recipients. Plastic and reconstructive surgeons are often faced with lesions that are located on aesthetic sensitive areas that are challenging to reconstruct such as the nose or the eyelid. For instance, lesions involving the full thickness of the nasal alar subunit may require a multiple-staged reconstruction with a forehead flap. However, it is paramount to pay close attention to the drugs that the patient may be on as they can affect flap survival even on the most robust locoregional flap such as the forehead flap. Hasegawa et al. conducted an animal study and found that TGF‐β enhanced granulation formation and reepithelialisation was significantly blocked when rabbits were exposed to the Tacrolimus transplant drug (1). Therefore, it is imperative that Transplant patients be treated in a multidisciplinary setting with the involvement of the transplant physician as well as the reconstructive surgeon to safely modulate the administration of immunosuppression drugs safely before surgery. This study aims to review the effects of immunosuppressive drugs on reconstructive surgery and present a case report of a transplant patient who required multiple surgeries due to the side effects of transplant medications. 1. Hasegawa T, Sumiyoshi K, Tsuchihashi H, Nakao A, Ogawa H. FK506 inhibits the enhancing effects of TGF‐beta on wound healing in a rabbit dermal ulcer model. J Dermatol Sci 2007;47:37–40