The history of angiosomes has played a pivotal role in the evolution of plastic surgery, particularly in the realms of tissue transfer and flap design. An angiosome is defined as a three-dimensional block of tissue supplied by a specific source vessel, with boundaries delineated by anastomotic perimeters or true anastomoses. The origins of angiosome theory trace back to the late 19th century with Carl Manchot's anatomical descriptions of skin perfusion in 1889. This was further developed through radiography by Salmon in 1936. However, the landmark contribution in this field was made by Taylor in 1987, whose seminal work established the principles of angiosomes, significantly influencing surgical techniques and the approach to tissue transfer. Taylor's principles of angiosomes include defining the territory of a flap, following the connective tissue framework, and the 'Law of Equilibrium', which states that if one vessel is small, its adjacent or contralateral vessel will be larger. The angiosome concept also introduced the idea of 'zones of perfusion', which has practical applications in procedures such as DIEP/TRAM flaps in breast reconstruction. Additionally, the understanding of choke vessels, which connect two vascular territories, has been instrumental. These vessels can be converted to true anastomoses through the delay phenomenon, a concept essential in flap surgery, and emphasize the dynamic nature of vascular territories in response to surgical manipulation. The history of angiosomes represents a fundamental chapter in the evolution of plastic surgery, offering a deeper understanding of vascular anatomy and its practical application in surgical procedures.