Purpose: Maintenance of pH and temperature are prerequisites for effective enzyme activity. While normothermic systems designed on the framework of cardiopulmonary bypass circuits or ECMO circuits have been in circulation, their ability to compensate for metabolic acidosis is limited. Therefore, they are not suitable platforms for organ resuscitation. In addition, the cost barrier prevents the uptake of the technology. This pilot study explored whether it was possible to modify a dialysis system to synchronously oxygenate and dialyse blood to create a novel normothermic perfusion machine. Methodology: A Baxter PrismaflexTM Dialysis System was modified to use oxygenated dialysate. Whole blood was used to perfuse 12 composite porcine abdominal blocks. Serial arterial and venous blood gas samples were taken to assess oxygenation across the dialysis membrane, oxygen consumption, carbon dioxide production and pH maintenance. Results: Oxygen transfer across the dialysis cartridge was effective, with significantly higher PaO2 (M = 318 mmHg, SD = 119) as compared to room air oxygenation (p<0.05). Oxygen consumption alongside carbon dioxide production was observed, with a baseline approximately three times that of normal resting tissue oxygen consumption. The dialysis function was able to maintain pH with a range of normality and the blocks were successfully perfused and preserved for 6 hours. Conclusion: The use of oxygenated dialysate allows the repurposing of existing medical equipment for normothermic preservation at a fraction of the cost currently available. Short-term outcomes in this study demonstrated the feasibility and efficacy of this technology.