Introduction: There is a paucity of data reflecting the changes in health-related quality of life (HRQoL) that thyroid cancer survivors experience. This systematic review was designed to identify and analyse published papers which have conducted assessments of thyroid cancer patient HRQoL at two or more timepoints. Methods: A systematic review was conducted of literature published in five databases. The keyword search included themes of thyroid cancer, HRQoL, and unmet needs. Only studies using validated, quantitative assessment tools were included. Two coders screened the relevant texts using Covidence. A narrative synthesis of data reported in the included studies was conducted. Results: An initial search of the five publication databases identified 9189 papers which met the search criteria. After removal of duplicates and studies not meeting the selection criteria, there were 32 papers for data extraction. A majority of studies were prospective cohort studies, with the next most common study type being RCTs. Generic tools were used much more commonly than thyroid-specific tools. The majority of HRQoL assessments occurred within the first 3 months, with a significant decrease in studies conducting measurements after 12 months. The most common context for HRQoL measurement was for observational studies, followed by studies designed to assess surgical interventions. Conclusion: Current studies demonstrate improvement in physical HRQoL in the first year. Clear data on the longer-term psychosocial impacts of thyroid cancer is limited by the heterogeneity of studies. Further prospective studies using validated tools as repeated measures over the longer term are required.